Axis intonation

I was setting the intonation on my Axis last night. I am tuned down to Eb. When setting the low E string, I noticed the 12th fret fretted note was a bit high compared to the open low E string. So proceeded to move the saddle away from the nut but there is no more adjustment available as the screw is right on the edge of the saddle. Has anyone else noticed this on their guitar? I am using the outermost hole in the saddle (hole nearest the nut)
Thanks in advance