Something wrong with my Majesty Bridge

Something wrong with my Majesty Bridge

The 6th string (fat E) is where the problem occurs. Downpicking is fine and sounds normal but when I up pick the string sounds weak, flat, dull, damp, dead.There are times that you can barely even hear the note being picked. It happens on any pickup setting, even Piezo. It doesn’t happen when I play unplugged (acousticly) , only when I’m using an amp or interface. The batteries are fresh, the strings have been changed a number of times. I’ve tried differen’t picks, I’ve tried using my fingers like I’m playing bass.

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Source: http://forums.ernieball.com